B8684

Bambuterol hydrochloride

>98% (HPLC), powder

• Synonyme(s) : Dimethylcarbmic acid 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene ester
• Formule linéaire : C₁₈H₂₉N₃O₅ · HCl
• CAS Number: 81732-46-9
• Poids moléculaire : 403.90
• Numéro MDL: MFCD03427293
• Code UNSPSC : 12352200
• ID de substance PubChem : 329773137
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: >98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: off-white
• Solubilité: H₂O: soluble ~33 mg/mL
• Auteur: AstraZeneca
• Chaîne SMILES: Cl.CN(C)C(=O)Oc1cc(OC(=O)N(C)C)cc(c1)C(O)CNC(C)(C)C
• InChI: 1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7;/h8-10,15,19,22H,11H2,1-7H3;1H
• Clé InChI: LBARATORRVNNQM-UHFFFAOYSA-N

Description

Description générale

Bambuterol is present in various tissues, like , intestine, lungs, liver and heart. It is also found in serum.

Application

Bambuterol hydrochloride has been used as a β2-adrenergic receptor (β2-AR) agonist to study its effects on graft versus host disease (GVHD) while preserving the graft-versus-tumor (GvT) effect. It has also been used in the preparation of bambuterol-poly vinyl chloride (Bb-PVC) membrane sensors for the determination of bambuterol in the pharmaceutical dosage form.

Actions biochimiques/physiologiques

β-adrenoceptor agonist; bronchodilator; anti-asthmatic; terbutaline prodrug

Bambuterol hydrochloride is used for prophylaxis and also to treat chronic bronchitis and chronic asthma in pediatrics.

Caractéristiques et avantages

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This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)