C0289

Cholesteryl linoleate

≥98% (HPLC; detection at 205 nm)

• Synonyme(s) : 3β-Hydroxy-5-cholestene 3-linoleate, 5-Cholesten-3β-ol 3-linoleate, Cholesteryl 9,12-octadecadienoate, Cholesteryl octadecadienoate
• Formule empirique (notation de Hill) : C₄₅H₇₆O₂
• CAS Number: 604-33-1
• Poids moléculaire : 649.08
• Numéro CE : 210-065-9
• Numéro MDL: MFCD00003644
• Code UNSPSC : 12352211
• ID de substance PubChem : 24892247
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥98% (HPLC; detection at 205 nm)
• Forme: powder
• Groupe fonctionnel: ester
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: CCCCC\C=C/C\C=C/CCCCCCCC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CC=C2C1)[C@H](C)CCCC(C)C
• InChI: 1S/C45H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h11-12,14-15,26,35-36,38-42H,7-10,13,16-25,27-34H2,1-6H3/b12-11-,15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
• Clé InChI: NAACPBBQTFFYQB-LJAITQKLSA-N

Description

Application

Cholesteryl linoleate was cosonicated with cholesterol to prepare dispersions were prepared to study the cholesterol to phospholipid ratio in red blood cell membrane. It was used as HPLC standard in the analysis of rat liver lipoproteins.

Actions biochimiques/physiologiques

Cholesteryl linoleate is a major cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters. The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.

The most abundant cholesteryl ester in low density lipoprotein (LDL).

Conditionnement

Sealed ampule

Notes préparatoires

Cholesteryl linoleate yields clear, colorless solution in chloroform at 100 mg/ml.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)