C1230

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

≥90% (TLC), powder

• Synonyme(s) : Z-IETD-FMK
• Formule empirique (notation de Hill) : C₃₀H₄₃FN₄O₁₁
• CAS Number: 220760-26-9
• Poids moléculaire : 654.68
• Numéro MDL: MFCD01861686
• Code UNSPSC : 12352209
• ID de substance PubChem : 329774744
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥90% (TLC)
• Forme: powder
• Solubilité: methanol: 10 mg/mL; DMSO: 20 mM, clear, colorless to light yellow
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
• InChI: 1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
• Clé InChI: CTXDBLYOEUERAT-VUVYEONESA-N

Description

Amino Acid Sequence

Z-Ile-Glu-OMe-Thr-Asp-OMe-FMK

Application

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:

• to study the activity of caspase-8 in porcine kidney cells
• to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells
• to study its effects on retinal ganglion and astroglia in rat eyes

Actions biochimiques/physiologiques

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.

Caractéristiques et avantages

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)