C174

Corticosterone: HBC complex

≥91.5% (HPLC), free flowing powder, water-soluble stress hormone

• CAS Number: 50-22-6
• Numéro MDL: MFCD00163376
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Corticosterone: HBC complex, free flowing powder
• Source biologique: synthetic (organic)
• Niveau de qualité: 100
• Stérilité: non-sterile
• Essai: ≥91.5% (HPLC)
• Forme: free flowing powder
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• Clé InChI: OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Description

Application

Corticosterone: HBC complex has been used:

• in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
• to induce acute stress in mice
• in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription

Actions biochimiques/physiologiques

The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule. Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.

Reconstitution

Corticosterone content: 66.7 mg/g. When 1 g of complex is reconstituted with water to a total volume of 2.12 mL, a solution which is 90.8 mM in corticosterone is obtained. Corticosterone itself is virtually insoluble in water.

Autres remarques

Preformed water-soluble complex of corticosterone and 2-hydroxypropyl-β-cyclodextrin. Package size is total weight of both the corticosterone and the 2-hydroxypropyl-β-cyclodextrin. Corticosterone content: 66.7 mg/g

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H312 + H332,H351
• Conseils de prudence: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges