C3742

Chk2 Inhibitor II hydrate

≥98% (HPLC)

• Synonyme(s) : 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
• Formule empirique (notation de Hill) : C₂₀H₁₄ClN₃O₂ · xH₂O
• CAS Number: 516480-79-8
• Poids moléculaire : 363.80 (anhydrous basis)
• Numéro MDL: MFCD08276917
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724438
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: off-white to tan
• Solubilité: DMSO: ≥2 mg/mL (warmed)
• Auteur: Johnson & Johnson
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(C1=CC=C2C(N=C(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)N2)=C1)N
• InChI: 1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
• Clé InChI: UXGJAOIJSROTTN-UHFFFAOYSA-N
• Informations sur le gène: human ... CHEK2(11200)

Description

Actions biochimiques/physiologiques

Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer.

Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC₅₀ = 15 nM; K_i = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC₅₀ = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC₅₀ = 3 μM and 7.6 μM, respectively).

Caractéristiques et avantages

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable