C4011

Cytochrome c from pigeon breast muscle

≥95% based on Mol. Wt. 12,173 basis

• CAS Number: 9007-43-6
• Numéro CE : 232-700-9
• Numéro MDL: MFCD00130890
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.61

Propriétés

• Source biologique: pigeon muscle (breast)
• Niveau de qualité: 200
• Essai: ≥95% based on Mol. Wt. 12,173 basis
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Température de stockage: −20°C

Description

Application

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.

Actions biochimiques/physiologiques

The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen.

Notes préparatoires

Prepared with acetic acid without using TCA.

Autres remarques

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)