C5749

CGP 52608

≥98%, solid

• Synonyme(s) : 1-[3-Allyl-4-oxo-thiazolidine-2-ylidene]-4-methyl-thiosemicarbazone, N-Methyl-2-[4-oxo-3-(2-propen-1-yl)-2-thiazolidinylidene]-hydrazinecarbothioamide
• Formule empirique (notation de Hill) : C₈H₁₂N₄OS₂
• CAS Number: 87958-67-6
• Poids moléculaire : 244.34
• Numéro MDL: MFCD00942304
• Code UNSPSC : 12352200
• ID de substance PubChem : 329775098
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98%
• Forme: solid
• Solubilité: DMSO: >30 mg/mL; H₂O: insoluble
• Température de stockage: −20°C
• Chaîne SMILES: CNC(=S)N\N=C1/SCC(=O)N1CC=C
• InChI: 1S/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8-
• Clé InChI: DDYJDIHOSRTMSE-FLIBITNWSA-N

Description

Application

CGP 52608 has been used as a RAR related orphan receptor α (RORα) synthetic agonist in THP-1 macrophages, in human monocyte cells THP1 and somatic testicular cells.

Actions biochimiques/physiologiques

CGP 52608 is a specific activator of retinoic acid receptor-related orphan receptor α (RORA).

CGP 52608 is a thiazolidine derivative and an antiarthritic compound. It possesses immunostimulatory functionality and elicits antiproliferative effect in colon tumors. It is cytotoxic towards neural cell lines. CGP 52608 induces apoptosis in tumor and also favors G0-G1 cell cycle phase accumulation in neural cell lines.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable