C6013

Cholesteryl hemisuccinate tris salt

anionic detergent

• Synonyme(s) : 3β-Hydroxy-5-cholestene 3-hemisuccinate, 5-Cholesten-3β-ol 3-hemisuccinate, CHEMS, CHS, Cholesteryl hydrogen succinate
• Formule empirique (notation de Hill) : C₃₁H₅₀O₄ · C₄H₁₁NO₃
• CAS Number: 102601-49-0
• Poids moléculaire : 607.86
• Numéro MDL: MFCD00058298
• Code UNSPSC : 12352211
• eCl@ss : 39023139
• ID de substance PubChem : 329775108
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Groupe fonctionnel: ester
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: NC(CO)(CO)CO.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O
• InChI: 1S/C31H50O4.C4H11NO3/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5;5-4(1-6,2-7)3-8/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33);6-8H,1-3,5H2/t21-,23+,24+,25-,26+,27+,30+,31-;/m1./s1
• Clé InChI: SLDYONDUXRBLLR-XTCKSVDZSA-N

Description

Application

Cholesteryl hemisuccinate tris salt has been used:

• to prepare solubilization buffer for glucan synthase assay
• to prepare immunoprecipitation buffer for immobilization of opioid receptors on paramagnetic beads.
• as a membrane stabilizer for liposomes and protein synaptogyrin-1
• as a component of a folate-modified self-microemulsifying drug delivery system.
• with N-dodecyl β-D-maltoside (DDM) to solubilize erythrocyte ghosts and chemokine receptor CCR1
• for protein solubilization

Actions biochimiques/physiologiques

Cholesteryl hemisuccinate is an ionizable anionic detergent that stabilizes large unilamellar vesicles. These liposome vesicles act as delivery agents for anticancer drugs, oligonucleotides and antibiotics. Cholesteryl succinate also reportedly exhibits antiproliferative activity and may be clinically useful as antitumor agent.

Notes préparatoires

Cholesteryl hemisuccinate tris salt yields clear, colorless solution in methanol at 10 mg/ml.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable