C6305

Clozapine

≥98% (TLC), powder, D₄-dopamine receptor antagonist

• Synonyme(s) : 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine
• Formule empirique (notation de Hill) : C₁₈H₁₉ClN₄
• CAS Number: 5786-21-0
• Poids moléculaire : 326.82
• Numéro MDL: MFCD00153785
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277892
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Clozapine,
• Forme: powder
• Niveau de qualité: 300
• Solubilité: ethanol: 1 mg/mL; 0.1 M HCl: 30 mg/mL; DMSO: 4.8 mg/mL
• Auteur: Novartis
• Chaîne SMILES: CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
• InChI: 1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
• Clé InChI: QZUDBNBUXVUHMW-UHFFFAOYSA-N
• Informations sur le gène: human ... ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HRH4(59340), HTR2A(3356), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR6(3362), HTR7(3363), KCNH1(3756), KCNH2(3757), UGT1A4(54657) ; rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Chrm1(25229), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2b(29581), Htr2c(25187), Htr3a(79246), Htr7(65032), Slc6a4(25553)

Description

Actions biochimiques/physiologiques

Atypical antipsychotic compound. Selective antagonist for D₄-dopamine receptor. Antagonist at 5-HT_2A, 5-HT_2C, 5-HT₃, 5-HT₆, and 5-HT₇ serotonin receptors.

Caractéristiques et avantages

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable