C6492

Ciproxifan hydrochloride

≥98% (HPLC), solid

• Synonyme(s) : Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]-methanone hydrochloride
• Formule empirique (notation de Hill) : C₁₆H₁₈N₂O₂ · HCl
• CAS Number: 1049741-81-2
• Poids moléculaire : 306.79
• Numéro MDL: MFCD08705321
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724449
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated; under inert gas
• Couleur: off-white
• Solubilité: DMSO: 30 mg/mL; water, high purity: 30 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2
• InChI: 1S/C16H18N2O2.ClH/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;/h5-8,10-12H,1-4,9H2,(H,17,18);1H
• Clé InChI: PWAPSKMHZQQTRJ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Ciproxifan belongs to a novel chemical series of histamine H₃-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H₃ autoreceptor controlling ³H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H₃ receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H₃ receptor labeled with ¹²⁵I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H₃-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

H₃ histamine receptor antagonist.

Caractéristiques et avantages

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves