C6499

CTB

≥98% (HPLC)

• Synonyme(s) : CTPB, N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide
• Formule empirique (notation de Hill) : C₁₆H₁₃ClF₃NO₂
• CAS Number: 451491-47-7
• Poids moléculaire : 343.73
• Numéro MDL: MFCD02356522
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: DMSO: >10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
• Clé InChI: YDXZSNHARVUYNM-UHFFFAOYSA-N

Description

Description générale

CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.

Application

CTB has been used to study its apoptotic effects on P53 protein acetylation.

Actions biochimiques/physiologiques

CBP (CREB binding protein)/p300) histone acetyltransferases (HATs) activator; p300 HAT activator.

CTPB was a first known small molecular activator of histone acetyltransferase p300. CTB is a simplified analog of CTPB with comparable or higher activity. The compound activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein.

Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2