C8739

Cyclin-Dependent Kinase 5 human

recombinant, expressed in E. coli BL21, 50-100 units/μg protein

• Numéro MDL: MFCD06201997
• Code UNSPSC : 12352204
• Nomenclature NACRES : NA.54

Propriétés

• Produit recombinant: expressed in E. coli BL21
• Niveau de qualité: 200
• Forme: solution
• Activité spécifique: 50-100 units/μg protein
• Conditionnement: vial of 300 units
• Conditions d'expédition: dry ice
• Température de stockage: −70°C

Description

Application

Human cyclin-dependent kinase 5 has been used in a study to determine its 3′ untranslated region subunit 1 contains regulatory elements that affect transcript stability.

Actions biochimiques/physiologiques

CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29.

Définition de l'unité

One unit will phosphorylate 1.0 picomole of the peptide substrate histone H1^9-18 per minute at 30 °C at pH 7.4.

Forme physique

Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)