C8874

CGP-37157

≥98% (HPLC), powder

• Synonyme(s) : 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
• Formule empirique (notation de Hill) : C₁₅H₁₁Cl₂NOS
• CAS Number: 75450-34-9
• Poids moléculaire : 324.22
• Numéro MDL: MFCD09055422
• Code UNSPSC : 12352200
• ID de substance PubChem : 329775189
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white
• Solubilité: DMSO: ≥20 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1
• InChI: 1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19)
• Clé InChI: KQEPIRKXSUIUTH-UHFFFAOYSA-N

Description

Description générale

CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist. CGP-37157 regulates intracellular signaling of calcium in smooth, cardiac and skeletal muscle cells and non-muscle systems.

Application

CGP-37157 has been used as a mitochondrial sodium-calcium exchanger (mNCX) inhibitor to study the role of normal mitochondrial calcium dynamics in sustaining dendritic spinogenesis.

Actions biochimiques/physiologiques

Specific inhibitor of mitochondrial Na⁺/Ca²⁺ exchange as well as sarcoplasmic reticulum calcium-stimulated ATPase and possibly other calcium channels.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3