C9124

CK-869

≥98% (HPLC)

• Synonyme(s) : 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone, CK 869, CK-0157869
• Formule empirique (notation de Hill) : C₁₇H₁₆BrNO₃S
• CAS Number: 388592-44-7
• Poids moléculaire : 394.28
• Numéro MDL: MFCD01844129
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to light gray
• Solubilité: DMSO: 10 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: S1C(N(C(=O)C1)c3c(cc(cc3)OC)OC)c2cc(ccc2)Br
• InChI: 1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3
• Clé InChI: MVWNPZYLNLATCH-UHFFFAOYSA-N

Description

Application

CK-869 has been used as an Arp2/3 complex inhibitor:

• to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
• to induce membrane blebbing in HT1080 fibrosarcoma cells
• to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

Actions biochimiques/physiologiques

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.

CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast.

CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable