D3072

Doxycycline Hydrochloride, Ready Made Solution

100 mg/mL in DMSO, ≥95.0% (HPLC)

• Synonyme(s) : α-6-Deoxy-5-hydroxytetracycline hydrochloride, 2-Naphthacenecarboxamide, 4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aR,5S,5aR,6R,12aS)-, Doxylin, Idocyklin, Vibramycin hyclate, Vibramycin hydrochloride
• Formule empirique (notation de Hill) : C₂₂H₂₄N₂O₈ · HCl
• CAS Number: 10592-13-9
• Poids moléculaire : 480.90
• Numéro MDL: MFCD03427564
• Code UNSPSC : 51284028
• Nomenclature NACRES : NA.85

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Stérilité: 0.22 μm filtered
• Essai: ≥95.0% (HPLC)
• Forme: liquid
• Concentration: 100 mg/mL in DMSO
• Solubilité: DMSO: 100 mg/mL
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria; mycoplasma; parasites
• Mode d’action: protein synthesis | interferes
• Température de stockage: −20°C
• InChI: 1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1
• Clé InChI: VLUQVUWDECWBTL-UQVCFKGQSA-N

Description

Description générale

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo.

Application

<ul>
<li><strong>AAPS PharmSciTech: </strong>Creation of a PVA/PCL/CS-based nanofibrous membrane incorporating doxycycline hydrochloride for guided tissue regeneration and controlled delivery in the management of periodontitis, evaluated in vivo in rats (Mirzaeei et al., 2024).</li>
<li><strong>European Journal of Pharmacology: </strong>Doxycycline hydrochloride′s role in inhibiting the progression of malignant rhabdoid tumor of the kidney by targeting MMP17 and MMP1 through the PI3K-Akt signaling pathway (Mi et al., 2024).</li>
</ul>

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 188.6 °F - closed cup
• Point d'éclair (°C): 87 °C - closed cup