D3630

Diphenhydramine hydrochloride

≥98% (HPLC)

• Synonyme(s) : 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride
• Formule empirique (notation de Hill) : C₁₇H₂₁NO · HCl
• CAS Number: 147-24-0
• Poids moléculaire : 291.82
• Numéro CE : 205-687-2
• Numéro MDL: MFCD00012479
• Code UNSPSC : 12352116
• ID de substance PubChem : 24277771
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: powder
• Auteur: Johnson & Johnson
• Chaîne SMILES: Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2
• InChI: 1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
• Clé InChI: PCHPORCSPXIHLZ-UHFFFAOYSA-N
• Informations sur le gène: human ... HRH1(3269)

Description

Application

Diphenhydramine hydrochloride has been used:
as a reference compound to study the long duration of action of antihistamine bilastine in vivo
to detect its embryotoxicity by embryonic stem cell test (EST) using cardiomyocyte differentiation and osteoblasts differentiation
as an antihistamine in experimental studies

Actions biochimiques/physiologiques

H1 histamine receptor antagonist
Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions. It exhibits antimuscarinic and marked sedative effects. DPH is also used to prevent nausea, vomiting and vertigo of various causes. In addition, it acts as a potential therapeutic for insomnia.

Caractéristiques et avantages

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves