D4268

N^G,N^G-Dimethylarginine dihydrochloride

≥98% (TLC), powder, NOS inhibitor

• Synonyme(s) : asym-Dimethylarginine, ADMA
• Formule empirique (notation de Hill) : C₈H₁₈N₄O₂ · 2HCl
• CAS Number: 220805-22-1
• Poids moléculaire : 275.18
• Numéro MDL: MFCD00270857
• Code UNSPSC : 12352209
• ID de substance PubChem : 24278027
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: N^G,N^G-Dimethylarginine dihydrochloride,
• Essai: ≥98% (TLC)
• Niveau de qualité: 200
• Forme: powder
• Solubilité: water: 50 mg/mL, clear, colorless
• Température de stockage: room temp
• Chaîne SMILES: Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O
• InChI: 1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
• Clé InChI: SYLNVYJOPZWPJI-ILKKLZGPSA-N
• Informations sur le gène: human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Description

Description générale

N^G,N^G-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

Application

N^G,N^G- Dimethylarginine dihydrochloride has been used:

• to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
• as a standard for measuring L-arginine and dimethylarginines
• to study its effects on hepatic deterioration

Actions biochimiques/physiologiques

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)