D6571

3′,4′-Dimethoxyflavone

• Synonyme(s) : 2-(3,4-Dimethoxyphenyl)chromen-4-one, 3′,4′-DMF
• Formule empirique (notation de Hill) : C₁₇H₁₄O₄
• CAS Number: 4143-62-8
• Poids moléculaire : 282.29
• Numéro MDL: MFCD00143009
• Code UNSPSC : 12352200
• ID de substance PubChem : 329798831
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: powder
• Couleur: white to off-white
• Solubilité: DMSO: ≥20 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: COc1ccc(cc1OC)C2=CC(=O)c3ccccc3O2
• InChI: 1S/C17H14O4/c1-19-15-8-7-11(9-17(15)20-2)16-10-13(18)12-5-3-4-6-14(12)21-16/h3-10H,1-2H3
• Clé InChI: ZGHORMOOTZTQFL-UHFFFAOYSA-N

Description

Application

3′,4′-Dimethoxyflavone has been used in urease inhibition assay.

Actions biochimiques/physiologiques

3′,4′-Dimethoxyflavone is a flavone compound, which has the ability to prevent the production and accumulation of poly (ADP-ribose) (PAR) polymer. It guards against N-methyl-D-aspartate (NMDA) toxicity in cortical neurons. 3′,4′-Dimethoxyflavone is a member of the class of plant-derived polyphenolic flavonoids. It is known to have antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidemic and neuroprotective or neurotrophic effects.

3′,4′-dimethoxyflavone is a competitive antagonist of the AhR that inhibits AhR-mediated induction of CYP1A1, and also displays antiestrogen activity in breast tumor cell lines. The compound blocks transformation of the cytosolic AhR complex, and formation of nuclear AhR complexes.

3′,4′-dimethoxyflavone is a competitive antagonist of the aryl hydrocarbon receptor (AhR) that inhibits AhR-mediated induction of CYP1A1, and also displays antiestrogen activity in breast tumor cell lines.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable