D7321

Diosmetin

• Synonyme(s) : 3′,5,7-Trihydroxy-4′-methoxyflavone, 4′-Methylluteolin, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one, Luteolin 4′-methyl ether
• Formule empirique (notation de Hill) : C₁₆H₁₂O₆
• CAS Number: 520-34-3
• Poids moléculaire : 300.26
• Beilstein: 294492
• Numéro CE : 208-291-8
• Numéro MDL: MFCD00017425
• Code UNSPSC : 12352205
• ID de substance PubChem : 329798848
• Nomenclature NACRES : NA.25

Propriétés

• Essai: ≥98% (HPLC)
• Niveau de qualité: 200
• Forme: powder
• Couleur: light yellow to yellow
• Solubilité: DMSO: 1 mg/mL, clear, faintly yellow to greenish-yellow
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
• Clé InChI: MBNGWHIJMBWFHU-UHFFFAOYSA-N

Description

Description générale

Diosmetin is a methylated aglycone flavone of diosmin. It is present abundantly in citrus fruits, Olea europaea L. (olive tree) leaves, and in the legume of Acacia farnesiana tree.

Application

Diosmetin has been used to test its protective effects on chronic stress memory and cognitive impairment in mice model.

Actions biochimiques/physiologiques

Diosmetin exhibits anti-inflammatory, anti-cancer, antimicrobial, phytoestrogenic, and neuroprotective properties. It displays cytoprotective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and activating nuclear factor erythroid 2–related factor 2 (Nrf2).

Flavonoid from Citrus limon. Antioxidant. Inhibits carcinogen activation by inhibiting the CYP1A1 enzyme.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable