D9305

1-Deoxynojirimycin hydrochloride

• Synonyme(s) : 1,5-Dideoxy-1,5-imino-D-sorbitol hydrochloride
• Formule empirique (notation de Hill) : C₆H₁₃NO₄ · HCl
• CAS Number: 73285-50-4
• Poids moléculaire : 199.63
• Beilstein: 3563225
• Numéro MDL: MFCD00133247
• Code UNSPSC : 12352201
• ID de substance PubChem : 24278397
• Nomenclature NACRES : NA.32

Propriétés

• Essai: ≥98% (TLC)
• Niveau de qualité: 200
• Forme: powder
• Solubilité: water: 19.60-20.40 mg/mL, clear, colorless
• Spectre d'activité de l'antibiotique: viruses
• Mode d’action: enzyme | inhibits
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl[H].OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/m1./s1
• Clé InChI: ZJIHMALTJRDNQI-VFQQELCFSA-N
• Informations sur le gène: human ... GAA(2548)

Description

Description générale

Chemical structure: glucosamine

Application

1-Deoxynojirimycin hydrochloride has been used

• to study its effects on the loss-of-function of N-glycosylation pathway on hair cell regeneration
• as an endoplasmic reticulum (ER) α-glucosidase I and II inhibitor to study its effects on TMED3-cystic fibrosis transmembrane conductance regulator (CFTR) interaction
• as an insect trehalase inhibitor in TREH inhibition bioassay

Actions biochimiques/physiologiques

α-Glucosidase inhibitor

1-Deoxynojirimycin (DNJ) is a naturally occurring alkaloid azasugar or iminosugar. It is observed in mulberry leaves, Commelina communis, and bacterial strains including Bacillus and Streptomyces species. DNJ acts as an α-glucosidase inhibitor and exhibits anti-viral anti-diabetic, anti-inflammatory, anti-obesity, and antioxidant properties.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)