E2764

Anti-Endothelin Receptor B antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonyme(s) : Anti-ET-B, Anti-ET-Specific Endothelin Receptor
• Numéro MDL: MFCD02677992
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: lyophilized powder
• Espèces réactives: rat
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100; western blot (chemiluminescent): 1:200
• Numéro d'accès UniProt: P21451
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: rat ... Ednrb(50672)

Description

Description générale

Endothelin Receptor B (EDNRB) is a G-protein coupled receptor and that consists of seven transmembrane domains. EDNRB gene is located on the human chromosome at 13q22.3.

Immunogène

synthetic peptide corresponding to amino acids 298-313 of rat endothelin receptor type B. The epitope is identical in all known vertebrate ET-B receptors

Application

Anti-Endothelin Receptor B antibody produced in rabbit has been used in immunohistochemistry (1:100).

Actions biochimiques/physiologiques

EDNRB Endothelin receptor type B (ETB) plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy. It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity.

Mutations in the EDNRB gene are associated with Hirschsprung disease.

Forme physique

Lyophilized at 0.8 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335,H412
• Conseils de prudence: P273 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Aquatic Chronic 3 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable