E4632

Econazole nitrate salt

• Synonyme(s) : 1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
• Formule empirique (notation de Hill) : C₁₈H₁₅Cl₃N₂O · HNO₃
• CAS Number: 24169-02-6
• Poids moléculaire : 444.70
• Numéro CE : 246-053-5
• Numéro MDL: MFCD00058160
• Code UNSPSC : 51102829
• ID de substance PubChem : 24894567
• Nomenclature NACRES : NA.85

Propriétés

• Forme: powder or crystals
• Niveau de qualité: 200
• Couleur: white to off-white
• Spectre d'activité de l'antibiotique: Gram-positive bacteria; fungi
• Mode d’action: cell membrane | interferes; cell wall synthesis | interferes; enzyme | inhibits
• Chaîne SMILES: O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
• InChI: 1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
• Clé InChI: DDXORDQKGIZAME-UHFFFAOYSA-N

Description

Description générale

Chemical structure: imidazole

Application

Econazole is a broad spectrum antimycotic similar to ketoconazole. It has some action against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. It is used for studies on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca²⁺ transport pathways in thymic lymphocytes.

Actions biochimiques/physiologiques

Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319
• Conseils de prudence: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves