E5156

Epinastine hydrochloride

≥98% (HPLC), solid

• Synonyme(s) : 9,13b-Dihydro-1H-dibenz[cf]imidazo[1,5-a]azepine hydrochloride, WAL-801Cl
• Formule empirique (notation de Hill) : C₁₆H₁₅N₃ · HCl
• CAS Number: 108929-04-0
• Poids moléculaire : 285.77
• Numéro MDL: MFCD00933434
• Code UNSPSC : 12352200
• ID de substance PubChem : 24894608
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Couleur: white
• Solubilité: H₂O: 38 mg/mL
• Auteur: Boehringer Ingelheim
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl[H].NC1=NCC2N1c3ccccc3Cc4ccccc24
• InChI: 1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H
• Clé InChI: VKXSGUIOOQPGAF-UHFFFAOYSA-N
• Informations sur le gène: human ... HRH1(3269)

Description

Description générale

Epinastine has antihistamine functions. In mast cells, it may modulate cytokine and chemokine production. In dendritic cells, it controls T helper cell mediated immune response. Epinastine hydrochloride does not traverse the brain barrier. Oral dosage of epinastine hydrochloride is prescribed for children with sleep-disordered breathing (SDB) and nasal inflammation. Ophthalmic solution of epinastine is effective for allergic conjunctivitis.

Actions biochimiques/physiologiques

Epinastine hydrochloride is a non-sedating H1 histamine receptor antagonist.

Caractéristiques et avantages

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges