E6530

Etomidate

>98% (HPLC), powder

• Synonyme(s) : (R)-1-(α-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester, Amidate, R16659
• Formule empirique (notation de Hill) : C₁₄H₁₆N₂O₂
• CAS Number: 33125-97-2
• Poids moléculaire : 244.29
• Numéro CE : 251-385-9
• Numéro MDL: MFCD00869295
• Code UNSPSC : 12352200
• ID de substance PubChem : 24894630
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: >98% (HPLC)
• Forme: powder
• Couleur: white
• Solubilité: DMSO: >10 mg/mL
• Auteur: Johnson & Johnson
• Température de stockage: 2-8°C
• Chaîne SMILES: CCOC(=O)c1cncn1[C@H](C)c2ccccc2
• InChI: 1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
• Clé InChI: NPUKDXXFDDZOKR-LLVKDONJSA-N
• Informations sur le gène: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)

Description

Description générale

Etomidate is an imidazole derivative, which functions as an nonbarbiturate hypnotic agent. It is used in speech and memory test. Etomidate regulates hemodynamic stability by preserving sympathetic outflow and autonomic reflexes. It inhibits adrenal steroidogenesis.

Actions biochimiques/physiologiques

Etomidate is a general anesthetic; potentiates GABA_A transmission

Etomidate is a general anesthetic; potentiates GABAA transmission. The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H410
• Conseils de prudence: P273 - P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves