E9780

Anti-Endothelin A Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonyme(s) : EDNRA, ENDOR, ET-AR, ETA, ETA RECEPTOR, ETRA, Endothelin Receptor Type A, Et1 receptor, Gpcr10, RATENDOR, Anti-ET-A Receptor
• Numéro MDL: MFCD01092540
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Espèces réactives: human
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3-16 μg/mL using human heart tissue
• Numéro d'accès UniProt: P25101
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... EDNRA(1909) ; mouse ... Ednra(13617) ; rat ... Ednra(24326)

Description

Immunogène

synthetic peptide corresponding to the third extracellular domain of human endothelin A receptor, conjugated to KLH. The immunizing peptide has 100% homology with mouse

Application

Anti-Endothelin A Receptor antibody produced in rabbitis suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 3-16μg/mL using human heart tissue.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Actions biochimiques/physiologiques

Endothelin A Receptor (ETA) is one of three endothelin receptors that mediates the effects of endothelin-1, a vasoconstrictor peptide. Located in the smooth muscle tissue of blood vessels, the interaction between endothelin and ETA plays a role in the regulation of blood pressure. Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETA mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.

Forme physique

Solution in phosphate buffered saline containing 0.1% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable