F6627

5-Fluorouracil

≥99% purity (HPLC), powder

• Synonyme(s) : 2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione
• Formule empirique (notation de Hill) : C₄H₃FN₂O₂
• CAS Number: 51-21-8
• Poids moléculaire : 130.08
• Beilstein: 127172
• Numéro CE : 200-085-6
• Numéro MDL: MFCD00006018
• Code UNSPSC : 12171500
• ID de substance PubChem : 24278439
• Nomenclature NACRES : NA.47

Propriétés

• Product Name: 5-Fluorouracil, ≥99% (HPLC), powder
• Essai: ≥99% (HPLC)
• Forme: powder
• Technique(s): titration: suitable
• Couleur: white
• Pf: 282-286 °C (dec.) (lit.)
• Solubilité: 1 M NH4OH: soluble; DMSO/DMF: soluble; methanol: soluble
• εmax: 7.07 at 265 nm in 0.1 M HCl
• Application(s): diagnostic assay manufacturing; hematology; histology
• Température de stockage: room temp
• Chaîne SMILES: FC1=CNC(=O)NC1=O
• InChI: 1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
• Clé InChI: GHASVSINZRGABV-UHFFFAOYSA-N
• Informations sur le gène: human ... TYMS(7298)

Description

Application

5-Fluorouracil has been used to induce apoptosis in cells. It has been used as a chemosensitizing agent.

Actions biochimiques/physiologiques

A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase, thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H351
• Conseils de prudence: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral - Carc. 2
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3