F6892

Farnesyl pyrophosphate ammonium salt

methanol:ammonia solution, ≥95% (TLC)

• Synonyme(s) : 3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl pyrophosphate ammonium salt, FPP
• Formule empirique (notation de Hill) : C₁₅H₃₇N₃O₇P₂
• CAS Number: 13058-04-3
• Poids moléculaire : 433.42
• Numéro MDL: MFCD00189688
• Code UNSPSC : 12352204
• ID de substance PubChem : 24894923
• Nomenclature NACRES : NA.83

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (TLC)
• Forme: methanol:ammonia solution
• Conditionnement: vial of 200 μg
• Température de stockage: −20°C
• Chaîne SMILES: C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
• InChI: 1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
• Clé InChI: VWFJDQUYCIWHTN-YFVJMOTDSA-N
• Informations sur le gène: rat ... Fnta(25318)

Description

Description générale

Farnesyl pyrophosphate is a 15-carbon isoprenoid synthesized from geranyl pyrophosphate (GPP) by the action of enzyme farnesyl pyrophosphate synthase (FPPS).

Application

Farnesyl pyrophosphate ammonium salt has been used:

• as a prenylation agonist in human osteogenic sarcoma cells in collagen-based cell invasion assays
• in the prenylation of the hepatocyte growth factor (HGF) in human umbilical vein endothelial cells (HUVECs)
• as a substrate in prenyltransferases assay in diatom Haslea ostrearia

Actions biochimiques/physiologiques

Farnesyl pyrophosphate (FPP) is the precursor for the biosynthesis of cholesterol, ubiquinone and dolicol. It is part of the intracellular mevalonate pathway. FPP is essential for cell survival and is used for prenylation of several low molecular mass G proteins, including Ras. Inhibition of prenylation results in loss of oncogenic potential of Ras proteins. Inhibition of prenylation may serve as therapeutic potential for management of synaptic plasticity and Alzheimer′s disease.

Forme physique

Solution in methanol: 10mM aqueous NH₄OH (7:3)
Actual concentration given on label

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H315,H319,H370,H412
• Conseils de prudence: P210 - P273 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 1
• Organes cibles: Eyes,Central nervous system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 60.8 °F
• Point d'éclair (°C): 16 °C