F8932

Fatostatin hydrobromide

≥98% (HPLC), powder

• Synonyme(s) : 25B11 hydrobromide, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide, Fatostatin A hydrobromide; 2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide
• Formule empirique (notation de Hill) : C₁₈H₁₈N₂S·HBr
• CAS Number: 298197-04-3
• Poids moléculaire : 375.33
• Numéro MDL: MFCD00760867
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: light yellow to yellow
• Solubilité: DMSO: ≥10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: [s]1c(nc(c1)c3ccc(cc3)C)c2cc(ncc2)CCC.Br
• InChI: 1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H
• Clé InChI: RJCFNQZVFUMORB-UHFFFAOYSA-N

Description

Description générale

Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor and antimitotic properties.

Application

Fatostatin hydrobromide has been used:

• to study its anti-cancer activity and effects on mitotic microtubule spindle
• to study its effects on stomatal development
• to prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)

Actions biochimiques/physiologiques

Fatostatin hydrobromide is an SREBP inhibitor.

Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable