F9786

Fibroblast Growth Factor-Basic Heparin Stabilized human

recombinant, expressed in E. coli, aqueous solution, suitable for cell culture

• Synonyme(s) : rhbFGF
• CAS Number: 106096-93-9
• Numéro MDL: MFCD00081382
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Fibroblast Growth Factor-Basic Heparin Stabilized human, FGF-Basic, recombinant, expressed in E. coli, sterile-filtered, aqueous solution, suitable for cell culture
• Source biologique: human
• Produit recombinant: expressed in E. coli
• Stérilité: sterile-filtered
• Forme: aqueous solution
• Puissance: 0.03-3.0 ng/mL ED₅₀/EC₅₀
• Qualité: endotoxin tested
• Conditionnement: pkg of 1 and 5 mL
• Technique(s): cell culture | mammalian: suitable
• Numéro d'accès UniProt: P09038
• Température de stockage: 2-8°C
• Informations sur le gène: human ... FGF2(2247)

Description

Description générale

Fibroblast growth factor 2 (FGF2), a canonical member, belongs to the fibroblast growth factor family.

Application

Fibroblast Growth Factor-Basic Heparin Stabilized human has been used to culture Brown Norway rat yolk sac epithelial cells transformed with mouse sarcoma virus (BN/MSV). It has also been used in the preparation of serum-free mouse tubal epithelium growth medium (M-TE-GM) to culture primary tubal epithelium (TE) cells.

Actions biochimiques/physiologiques

Fibroblast growth factor 2 (FGF2) participates in tissue development and repair. It is also involved in embryonic development, angiogenesis, bone regeneration, stem cell self-renewal, and wound healing. The basic fibroblast growth factor (bFGF) plays a key role in the progression and maintenance of the nervous system. FGF2 binds to the FGF receptor (FGFR) and activates the extracellular signal-regulated kinase (ERK) pathway, which controls cellular behavior, using heparan sulfates (HS)/heparin as a cofactor. bFGF stimulates cell proliferation, differentiation, and migration in a variety of cell types. In cultured astrocytes from rat brain, recombinant human basic fibroblast growth factor (rhbFGF) may induce nerve growth factor (NGF) secretion. It is the heparin stabilized form of a natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)