G1043

Guanfacine hydrochloride

≥98% (HPLC)

• Synonyme(s) : N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide
• Formule empirique (notation de Hill) : C₉H₉Cl₂N₃O · HCl
• CAS Number: 29110-48-3
• Poids moléculaire : 282.55
• Numéro MDL: MFCD00798230
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278452
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Couleur: white
• Solubilité: H₂O: soluble 12 mg/mL at 60 °C
• Auteur: Promius
• Chaîne SMILES: Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl
• InChI: 1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
• Clé InChI: DGFYECXYGUIODH-UHFFFAOYSA-N
• Informations sur le gène: human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Application

Guanfacine hydrochloride has been used as an α2A adrenoceptor agonist to test its protective effect on hypobaric hypoxia (HH) and in rat brain to measure blood oxygenation level dependent (BOLD) response.

Actions biochimiques/physiologiques

Guanfacine stimulates the brain postsynaptic α2 adrenergic receptor (AR) and mediates the prefrontal cortical (PFC) neuronal regulation and strengthens their network. Guanfacine improves the density of neuronal dendrites and is useful in treating neuropsychiatric disorders. It modulates the synaptic and cytoskeletal proteins expression in prefrontal cortical (PFC) neurons and may improve hypobaric hypoxia (HH) induced PFC dysfunctions. Guanfacine enhances cognitive function and is recommended for attention deficit hyperactivity disorder (ADHD) therapy.

α-2 noradrenergic receptor agonist.

Caractéristiques et avantages

This compound was developed by Promius. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)