G119

GYKI 52466 hydrochloride

solid

• Synonyme(s) : 1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
• Formule empirique (notation de Hill) : C₁₇H₁₅N₃O₂ · HCl
• CAS Number: 192065-56-8
• Poids moléculaire : 329.78
• Numéro MDL: MFCD00153803
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277984
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Couleur: yellow
• Solubilité: DMSO: 0.39 mg/mL; ethanol: 0.4 mg/mL; 0.1 M HCl: 0.68 mg/mL; methanol: 1 mg/mL; H₂O: >10 mg/mL
• Chaîne SMILES: Cl[H].CC1=NN=C(c2ccc(N)cc2)c3cc4OCOc4cc3C1
• InChI: 1S/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H
• Clé InChI: RUBSCPARMVJNKX-UHFFFAOYSA-N
• Informations sur le gène: human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

Description

Application

GYKI 52466 hydrochloride has been used as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor selective antagonist in cell viability assays to evaluate the specificity of kainate (KA) effect on cerebellar granule cells (CGCs). It has also been used as an AMPA blocker to study the function of glutamate in neuroadapted sindbis virus (NSV) -induced motor neuron death.

Actions biochimiques/physiologiques

GYKI 52466 serves as an antagonist of several processes, mediated by glutamate.

Selective allosteric AMPA receptor antagonist; anti­convulsant; skeletal muscle relaxant.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations légales

Sold under exclusive license from the Institute for Drug Research Ltd., Budapest, Hungary.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves