G3416

5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate

solid, ≥98% (HPLC)

• Synonyme(s) : GNTI
• Formule empirique (notation de Hill) : C₂₇H₂₉N₅O₃ · 2C₂HF₃O₂ · xH₂O
• CAS Number: 219655-57-9
• Poids moléculaire : 699.60 (anhydrous basis)
• Numéro MDL: MFCD29923417
• Code UNSPSC : 12352202
• ID de substance PubChem : 24278454
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Solubilité: H₂O: 30 mg/mL
• Température de stockage: 2-8°C
• Informations sur le gène: human ... OPRK1(4986)

Description

Application

5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate (GNTI) has been used as a selective κ opioid receptor antagonist:

• to study the influence of opioid receptor types on the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitors in inflammation
• to study the role of κ opioid receptor in the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB)
• to validate its inhibitory actions on Akt kinase activities

Actions biochimiques/physiologiques

5′-Guanidinonaltrindole di(trifluoroacetate) (GNTI) is a 5‘-guanidine derivative and a selective κ opiate receptor antagonist. It is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the κ opioid receptor in smooth muscle preparations.

Caractéristiques et avantages

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations légales

Sold under US Patent No. 6,500,824.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)