G6793

GW7647

≥98% (HPLC)

• Synonyme(s) : 2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)­phenyl­thio)-2-methyl­propionic acid
• Formule empirique (notation de Hill) : C₂₉H₄₆N₂O₃S
• CAS Number: 265129-71-3
• Poids moléculaire : 502.75
• Numéro MDL: MFCD06798379
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278790
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Couleur: white
• Solubilité: DMSO: soluble 16 mg/mL; H₂O: insoluble
• Chaîne SMILES: CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(O)=O
• InChI: 1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
• Clé InChI: PKNYXWMTHFMHKD-UHFFFAOYSA-N
• Informations sur le gène: human ... PPARA(5465)

Description

Application

GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand:

• in defatting medium to treat primary human hepatocytes
• to test its effect on the glycolytic function in cardiomyocytes
• to test its effect on infant mouse heart
• in breast cancer MDA-MB-231 cells to activate PPARs

Actions biochimiques/physiologiques

GW7647 reduces serum triglyceride levels and enhances hepatic expression of genes associated with β-oxidation. Usage of GW7647 along with metformin in conditions of liver steatosis or injury improves the enzymatic levels of aspartate transaminase (AST) and alanine transaminase (ALT) in serum.

Potent human PPARα agonist. Use to study the biology of PPARα receptor in human cells.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations légales

Sold for research purposes only under agreement from Glaxo­Smith­Kline

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)