G8166

Glucagon-Like Peptide 2 -Arg human trifluoroacetate salt

>90% (HPLC), solid

• Synonyme(s) : GLP-2-Arg, Preproglucagon 126-159
• Formule empirique (notation de Hill) : C₁₇₁H₂₆₆N₄₈O₅₆S
• CAS Number: 99120-49-7
• Poids moléculaire : 3922.29
• Numéro MDL: MFCD00081649
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 200
• Essai: >90% (HPLC)
• Forme: solid
• Numéro d'accès UniProt: P01275
• Température de stockage: −20°C
• Informations sur le gène: human ... GCG(2641)

Description

Amino Acid Sequence

His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-Arg

Description générale

Glucagon-like peptide 2 (GLP-2) is a member of the pro-glucagon gene family which is released in small and large intestinal circulation by enteroendocrine L cells. This peptide is composed of 33 amino acids.

Application

Glucagon-Like Peptide 2 (GLP-2) -Arg human trifluoroacetate salt has been used for injection in chickens to determine the effects of GLP-2 on the weight and morphology of small intestines.

Actions biochimiques/physiologiques

Glucagon-like peptide 2 (GLP-2) influences the functionality of gastrointestinal tract by participating in the feedback loop to the brain for the control of food intake. It also controls digestion and absorption, and has tropic effects post chemotherapy injury or surgical resection. This peptide is also responsible for epithelial cell proliferation of the small bowel. Studies in rats show that this peptide enhances the effects of the ileal-brake hormones, GLP-1 and peptide YY. It also negatively regulates gastrointestinal motility and secretion. Thus, it has potential as a therapeutic agent in short-bowel syndrome.

Glucagon-like peptide 2 is a neuropeptide that inhibits food intake when injected into the lateral ventricles of the brain and may mediate satiety. It is also a growth factor that stimulates proliferation and blocks apoptosis of intestinal epithelial cells.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)