H5915

2,3-Bis(4-hydroxyphenyl)propionitrile

≥98% (HPLC)

• Synonyme(s) : DPN, Diarylpropionitrile, SC-4473
• Formule empirique (notation de Hill) : C₁₅H₁₃NO₂
• CAS Number: 1428-67-7
• Poids moléculaire : 239.27
• Numéro MDL: MFCD01695412
• Code UNSPSC : 51111800
• ID de substance PubChem : 329815224
• Nomenclature NACRES : NA.77

Propriétés

• Stérilité: non-sterile
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: DMSO: 10 mg/mL, clear
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
• InChI: 1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
• Clé InChI: GHZHWDWADLAOIQ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

2,3-Bis(4-hydroxyphenyl)-propionitrile (Diarylprepionitrile, DPN) is an ERβ-selective agonist; IC₅₀ = 15nM. DPN protects WT and ARKO mice and significantly decreases IL-1β following LPS treatment in young adult-derived microglia. PPT (Cat. No.H6036, ERa agonist) enhances cell proliferation, while DPN inhibits it. PPT increases Bcl-2 expression, while DPN decreases it. DPN also elevates Bax expression. DPN induces a dose-dependent increase on vitellogenin synthesis. PPT and DPN are effective in dynamically, but differentially regulating intracellular calcium signaling in hippocampal neurons. DPN is more efficacious than PPT in potentiating a physiological concentration of glutamate-induced intracellular Ca²⁺ rise in these neurons. DPN prevents the development of prostatic hyperplasia and inflammation in testosterone-treated LuRKO mice.

2,3-Bis(4-hydroxyphenyl)-propionitrile is an ERβ-selective agonist; IC₅₀ = 15nM.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H319,H400
• Conseils de prudence: P273 - P305 + P351 + P338
• Classification des risques: Aquatic Acute 1 - Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves