H6649

Herbimycin A from Streptomyces hygroscopicus

≥95% (HPLC), powder

• Formule empirique (notation de Hill) : C₃₀H₄₂N₂O₉
• CAS Number: 70563-58-5
• Poids moléculaire : 574.66
• Beilstein: 4834067
• Numéro MDL: MFCD00151702
• Code UNSPSC : 12352200
• ID de substance PubChem : 24895756
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: Streptomyces hygroscopicus
• Niveau de qualité: 200
• Essai: ≥95% (HPLC)
• Forme: powder
• Couleur: yellow
• Solubilité: DMSO: 7.5 mg/mL
• Spectre d'activité de l'antibiotique: viruses
• Mode d’action: enzyme | inhibits
• Température de stockage: −20°C
• Chaîne SMILES: CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O
• InChI: 1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
• Clé InChI: MCAHMSDENAOJFZ-BVXDHVRPSA-N

Description

Description générale

DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic. It is an analog of geldanamycin.

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

Actions biochimiques/physiologiques

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.

Attention

Hygroscopic and photosensitive

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)