H9538

HNE-DMA

hexane solution, ≥85% (GC)

• Synonyme(s) : (E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA
• Formule empirique (notation de Hill) : C₁₁H₂₂O₃
• Poids moléculaire : 202.29
• Numéro MDL: MFCD07370138
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724506
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥85% (GC)
• Forme: hexane solution
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: CCCCCC(O)\C=C\C(OC)OC
• InChI: 1S/C11H22O3/c1-4-5-6-7-10(12)8-9-11(13-2)14-3/h8-12H,4-7H2,1-3H3/b9-8+
• Clé InChI: ATGIHMSJAARJTF-CMDGGOBGSA-N

Description

Actions biochimiques/physiologiques

Stable form of HNE; toxic second messenger of free radicals.

Notes préparatoires

To prepare HNE from HNE-DMA: evaporate the hexane under a gentle stream of nitrogen at room temperature. Working at 4 °C, add 1 ml (5 mg size) or 0.4 ml (2 mg size) of 1 mM cold HCl and stir for 45 minutes, or alternatively, close the vial and shake for 30 minutes. Upon hydrolysis, the initially cloudy solution becomes almost clear. This solution now has a pH of ∼3, contains ∼5 mg (5 mg size) or ∼2 mg (2 mg size) of the aldehyde (HNE), and is stable for at least 24 hours if kept at 4 °C. 6.8 mg HNE-DMA in 1 mL of hexane solution, giving 5 mg of HNE after hydrolysis.It is recommended that the freshly prepared HNE solution be used immediately.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS08,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H225,H304,H315,H336,H361f,H372,H411
• Conseils de prudence: P202 - P210 - P273 - P301 + P310 - P303 + P361 + P353 - P331
• Classification des risques: Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3
• Organes cibles: Central nervous system, Nervous system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): -14.8 °F - closed cup
• Point d'éclair (°C): -26 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter