I0160

Imipenem monohydrate

≥98% (HPLC)

• Synonyme(s) : (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate, Primaxin monohydrate, Tienam monohydrate
• Formule empirique (notation de Hill) : C₁₂H₁₇N₃O₄S · H₂O
• CAS Number: 74431-23-5
• Poids moléculaire : 317.36
• Numéro CE : 264-734-5
• Numéro MDL: MFCD09753321
• Code UNSPSC : 12352200
• ID de substance PubChem : 329815301
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D +73 to +84°, c = 0.5 in water
• Couleur: white to beige
• Solubilité: H₂O: >5 mg/mL
• Spectre d'activité de l'antibiotique: mycobacteria
• Mode d’action: cell wall synthesis | interferes
• Auteur: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Température de stockage: −20°C
• Chaîne SMILES: O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O
• InChI: 1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1
• Clé InChI: GSOSVVULSKVSLQ-JJVRHELESA-N

Description

Description générale

Chemical structure: ß-lactam

Application

Imipenem monohydrate has been used to determine the resistance profiles of Pseudomonas aeruginosa isolates. It has also been used in susceptibility testing against Acinetobacter baumannii.

Actions biochimiques/physiologiques

Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.

Imipenem monohydrate is a broad spectrum B-lactam antibiotic.

Imipenem monohydrate is a broad spectrum B-lactam antibiotic. It is a member of the carbapenem class of "magic bullet" antibiotics for severe infections.

Caractéristiques et avantages

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)