I2765

Ibotenic acid

~95% (TLC), solid, neurotoxin

• Synonyme(s) : α-Amino-3-hydroxy-5-isoxazoleacetic acid
• Formule empirique (notation de Hill) : C₅H₆N₂O₄
• CAS Number: 2552-55-8
• Poids moléculaire : 158.11
• Numéro MDL: MFCD00069294
• Code UNSPSC : 12352209
• ID de substance PubChem : 24277994
• Nomenclature NACRES : NA.32

Propriétés

• Product Name: Ibotenic acid, ~95%, solid
• Essai: ~95%
• Niveau de qualité: 100
• Forme: solid
• Couleur: white
• Solubilité: H₂O: 1 mg/mL, clear, colorless (with sonication); 0.1 M NaOH: 10.7 mg/mL; 0.1 M HCl: 4.7 mg/mL
• Chaîne SMILES: NC(C(O)=O)C1=CC(=O)NO1
• InChI: 1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
• Clé InChI: IRJCBFDCFXCWGO-UHFFFAOYSA-N
• Informations sur le gène: rat ... Grm1(24414), Grm2(24415)

Description

Application

Ibotenic acid has been used as a neurontoxin in rats. It has also been used in inducing a primary permanent lesion monkey cortex M1 neurons.

Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes.

Actions biochimiques/physiologiques

Ibotenic acid is an analog of glutamate. It is involved in the excitation of cell bodies and destroys the thalamic reticular nucleus (NRT). It induces high calcium influx leading to neuronal injury. Ibotenic acid is used to induce neurodegeneration due to its excitotoxic functionality.

Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin.

Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin; neuroexcitatory amino acid originally isolated from Amanita species.

Attention

Hygroscopic

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P301 + P310 + P330
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges