I3525

Interleukin-17A human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Synonyme(s) : CTLA-8, IL-17
• Numéro MDL: MFCD01094096
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Niveau de qualité: 100
• Produit recombinant: expressed in E. coli
• Essai: ≥98% (SDS-PAGE)
• Forme: lyophilized powder
• Puissance: ≤2.0 ng/mL ED₅₀
• Poids mol.: 31 kDa
• Conditionnement: pkg of 50 μg
• Technique(s): cell culture | mammalian: suitable
• Impuretés: endotoxin, tested (endotoxin level is less than 0.1 ng per μg cytokine (1 EU/μg).)
• Numéro d'accès UniProt: Q16552
• Température de stockage: −20°C
• Informations sur le gène: human ... IL17A(3605)

Description

Actions biochimiques/physiologiques

IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.

Initially known as CTLA-8; is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system; has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.

Forme physique

Lyophilized with no additives.

Remarque sur l'analyse

• The biological activity of human IL-17 is measured by its ability to induce IL-6 production using NHDF cells.
• Biological activity is also determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)