I3657

Insulin-Like Growth Factor Binding Protein-2 from mouse

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

• Synonyme(s) : IGFBP-2
• Numéro MDL: MFCD02099094
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: mouse
• Niveau de qualité: 200
• Produit recombinant: expressed in NSO cells
• Essai: ≥95% (SDS-PAGE)
• Forme: lyophilized powder
• Puissance: 0.125-0.5 mg per mL ED₅₀
• Poids mol.: ~35 kDa by SDS-PAGE (reducing); calculated mol wt 29.4 kDa
• Conditionnement: pkg of 25 μg
• Technique(s): cell culture | mammalian: suitable
• Impuretés: endotoxin, tested
• Numéro d'accès UniProt: D3YU40
• Température de stockage: −20°C
• Informations sur le gène: mouse ... Igfbp2(16008)

Description

Description générale

IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein.

Actions biochimiques/physiologiques

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.

Exhibits a 2-10 fold higher affinity for IGF II than for IGF I.

IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors.

Forme physique

Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.

Remarque sur l'analyse

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)