I5659

Idevenone

≥98% (HPLC), powder

• Synonyme(s) : 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
• Formule empirique (notation de Hill) : C₁₉H₃₀O₅
• CAS Number: 58186-27-9
• Poids moléculaire : 338.44
• Numéro MDL: MFCD00274552
• Code UNSPSC : 12352204
• ID de substance PubChem : 329815386
• Nomenclature NACRES : NA.25

Propriétés

• Product Name: Idevenone, ≥98% (HPLC)
• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: powder
• Solubilité: methanol: 50 mg/mL, clear to slightly hazy
• Température de stockage: room temp
• Chaîne SMILES: O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O
• InChI: 1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
• Clé InChI: JGPMMRGNQUBGND-UHFFFAOYSA-N

Description

Description générale

Idebenone is a short-chain benzoquinone drug.

Application

Idebenone has been used:

• to treat mutant myocilin (mMYOC) cells for drug treatment assay
• to validate C2C12 secondary cell screening assay
• to treat obese mice, to test whether idebenone and CoQ10 bind directly to peroxisome proliferator-activated receptor (PPAR)LBDs, His-tagged PPARα, δ and γ LBDs

Actions biochimiques/physiologiques

A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.

Idebenone is used in the treatment of visual impairment in adolescents and adults with Leber′s hereditary optic neuropathy (LHON). It serves as an antioxidant. It helps to guard the heart muscle against oxidative stress.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable