I7159

Monoclonal Anti-Interleukin-4 antibody produced in mouse

clone 3010, purified immunoglobulin, lyophilized powder

• Synonyme(s) : Anti-IL-4
• Numéro MDL: MFCD00212213
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 3010, monoclonal
• Forme: lyophilized powder
• Espèces réactives: human
• Technique(s): capture ELISA: suitable; western blot: 1-2 μg/mL
• Isotype: IgG1
• Numéro d'accès UniProt: P05112
• Température de stockage: −20°C
• Informations sur le gène: human ... IL4(3565)

Description

Description générale

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4 have been reported in cancers of breast, liver and renal cells
Anti-Interleukin-4 specifically recognizes human interleukin-4.

Immunogène

purified, E. coli-derived recombinant human interleukin-4.

Application

Anti-Interleukin-4 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA, a working concentration of 4 μg/ml is recommended.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)