I8250

3-Iodo-L-tyrosine

• Synonyme(s) : 3-Monoiodo-L-tyrosine
• Formule linéaire : IC₆H₃-4-(OH)CH₂CH(NH₂)CO₂H
• CAS Number: 70-78-0
• Poids moléculaire : 307.09
• Beilstein: 2941266
• Numéro CE : 200-744-8
• Numéro MDL: MFCD00002608
• Code UNSPSC : 12352200
• eCl@ss : 32160406
• ID de substance PubChem : 24278154
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 200
• Impuretés: ~5% tyrosine
• Pf: 210 °C (dec.) (lit.)
• Solubilité: dilute aqueous acid: soluble
• Température de stockage: −20°C
• Chaîne SMILES: N[C@@H](Cc1ccc(O)c(I)c1)C(O)=O
• InChI: 1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
• Clé InChI: UQTZMGFTRHFAAM-ZETCQYMHSA-N
• Informations sur le gène: human ... TH(7054)

Description

Description générale

Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).

Application

3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.

Actions biochimiques/physiologiques

3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.

TH (tyrosine 3-hydroxylase) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. Mutations in TH are associated with tyrosine hydroxylase deficiency, leading to conditions such as infantile parkinsonism and DOPA (dopamine)-responsive dystonia as well as encephalopathy with perinatal onset.

Tyrosine hydroxylase inhibitor.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)