K1514

Kurtoxin

• Formule empirique (notation de Hill) : C₃₂₄H₄₇₈N₉₄O₉₀S₈
• Poids moléculaire : 7386.36
• Numéro MDL: MFCD04119124
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Forme: solid
• Niveau de qualité: 200
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Informations sur le gène: human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911) ; mouse ... CACNA1G(12291), CACNA1H(58226), CACNA1I(239556) ; rat ... CACNA1G(29717), CACNA1H(114862), CACNA1I(56827)

Description

Amino Acid Sequence

Lys-Ile-Asp-Gly-Tyr-Pro-Val-Asp-Tyr-Trp-Asn-Cys-Lys-Arg-Ile-Cys-Trp-Tyr-Asn-Asn-Lys-Tyr-Cys-Asn-Asp-Leu-Cys-Lys-Gly-Leu-Lys-Ala-Asp-Ser-Gly-Tyr-Cys-Trp-Gly-Trp-Thr-Leu-Ser-Cys-Tyr-Cys-Gln-Gly-Leu-Pro-Asp-Asn-Ala-Arg-Ile-Lys-Arg-Ser-Gly-Arg-Cys-Arg-Ala

Description générale

Kurtoxin is hydrophobic in nature and shares sequence identity with α-scorpion and has cysteine-stabilized α-helix and β-sheet (CSαβ) motif. It interacts with N-type, and P-type calcium (Ca²⁺) channels as well.

Application

Kurtoxin has been used as a blocker of T-type and R-Type voltage-gated calcium channels (VGGCs) in hippocampal neurons.

Actions biochimiques/physiologiques

Kurtoxin is isolated from the venom of the South African scorpion Parabuthus transvaalicus. It associates with voltage-gated sodium channels and delays their inactivation.

T-type Ca²⁺ channel blocker; Scorpion toxin

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)