K3125

Kojic acid

≥98.5% (HPLC), powder, tyrosinase inhibitor

• Synonyme(s) : 2-Hydroxymethyl-5-hydroxy-γ-pyrone, 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone
• Formule empirique (notation de Hill) : C₆H₆O₄
• CAS Number: 501-30-4
• Poids moléculaire : 142.11
• Beilstein: 120895
• Numéro CE : 207-922-4
• Numéro MDL: MFCD00006580
• Code UNSPSC : 12352106
• ID de substance PubChem : 24896226
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Kojic acid,
• Essai: ≥98.5% (HPLC)
• Niveau de qualité: 200
• Forme: powder
• Pf: 152-155 °C (lit.)
• Chaîne SMILES: OCC1=CC(=O)C(O)=CO1
• InChI: 1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
• Clé InChI: BEJNERDRQOWKJM-UHFFFAOYSA-N

Description

Application

Kojic acid has been used:

• as an inhibitor of tyrosinase in guinea pigs pigmented hyperopic (PH)
• as a reference inhibitor standard for screening tyrosinase inhibition
• as a positive control for inhibition of tyrosinase in B16F10 melanoma cells

Actions biochimiques/physiologiques

Kojic acid is derived from some fungal species such as, Aspergillus, Acetobacter and Penicillium.. It halts melanin synthesis by inhibiting tyrosinase enzyme. It is used in the preparation of skin whitening cosmetics. However, kojic acid usage is minimal in cosmetics, as it induces skin irritation by its unstability and cytotoxic nature during long storage. It is an antioxidant and elicits radioprotective effects on chelating with manganese and zinc.

Tyrosinase inhibitor.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)