K4264

KR-62436 hydrate

≥95%, powder

• Synonyme(s) : 6-{2-[(5-Cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile dihydrochloride hydrate
• Formule empirique (notation de Hill) : C₁₄H₁₅N₇O·2HCl · xH₂O
• CAS Number: 761414-79-3
• Poids moléculaire : 370.24 (anhydrous basis)
• Numéro MDL: MFCD17215675
• Code UNSPSC : 51111800
• ID de substance PubChem : 24724521
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥95%
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: 5 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: O.Cl.Cl.O=C(CNCCNc1ccc(cn1)C#N)N2N=CCC2C#N
• InChI: 1S/C14H15N7O.2ClH.H2O/c15-7-11-1-2-13(19-9-11)18-6-5-17-10-14(22)21-12(8-16)3-4-20-21;;;/h1-2,4,9,12,17H,3,5-6,10H2,(H,18,19);2*1H;1H2
• Clé InChI: FQZOFSJMRKZMSV-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

KR-62436 is a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV). DPP-IV is a serine protease which inactivates glucagon-like peptide (GLP-1); IC₅₀ 0.1-0.8 μM; GLP-1 is a potent stimulus for insulin secretion and inducer of satiety after food intake, but it has a very short action (1 min) because it is rapidly degraded by DPP-IV; blocking DPP-IV increases GLP-1 action and increases plasma insulin levels; DPP-IV inhibitors and KR-62436 have clinical potential as anti-diabetic agents

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves