L0649

Leupeptin hydrochloride

powder, ≥70% (HPLC)

• Synonyme(s) : Acetyl-Leu-Leu-Arg-al hydrochloride
• Formule empirique (notation de Hill) : C₂₀H₃₈N₆O₄ · HCl
• CAS Number: 24125-16-4
• Poids moléculaire : 463.01
• Numéro MDL: MFCD00133457
• Code UNSPSC : 12352202
• ID de substance PubChem : 24896263
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Leupeptin hydrochloride, microbial, ≥70% (HPLC)
• Source biologique: microbial
• Niveau de qualité: 200
• Essai: ≥70% (HPLC)
• Forme: powder
• Solubilité: water: 50 mg/mL, clear, colorless to yellow
• Température de stockage: −20°C
• Chaîne SMILES: Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O
• InChI: 1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H
• Clé InChI: OQQYPQNFLLAILR-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Remarque sur l'analyse

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)