L1920

LY255283

≥98% (HPLC), powder

• Synonyme(s) : 1-(5-Ethyl-2-hydroxy-4-(6-methyl-6-(1H-tetrazol-5-yl)heptyloxy)phenyl)ethanone
• Formule empirique (notation de Hill) : C₁₉H₂₈N₄O₃
• CAS Number: 117690-79-6
• Poids moléculaire : 360.45
• Numéro MDL: MFCD00876422
• Code UNSPSC : 12352204
• ID de substance PubChem : 329817396
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white to light yellow
• Solubilité: DMSO: >20 mg/mL
• Auteur: Eli Lilly
• Température de stockage: −20°C
• Chaîne SMILES: CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c2nnn[nH]2
• InChI: 1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23)
• Clé InChI: WCGXJPFHTHQNJL-UHFFFAOYSA-N

Description

Application

LY255283, a competitive leukotriene B4 receptor antagonist, is used in leukotriene receptor research along with other selective leukotriene receptor agonists and antagonist to identify and differentiate the physiological and cell signaling effects of the leukotriene B4 receptor on processes such as paclitaxel resistance in MCF-7/DOX breast cancer cells, monocyte-derived dendritic cell chemotaxis, and 5-lipoxygenase activity and interleukin-8 production in human neutrophils. LY255283 may be used to help verify that an observed process or cell event is leukotriene B4 receptor-dependent.

Actions biochimiques/physiologiques

LY255283 is a competitive leukotriene B₄ receptor antagonist, specific to the BLT2 receptor subtype.

LY255283 is a competitive leukotriene B₄ receptor antagonist, with an IC₅₀ of about 100 nM. It is somewhat selective for the BLT2 receptor, since IC₅₀ values at the BLT1 receptor are >10 μM. LY255283 reduces airway obstruction in animal models of asthma.

Caractéristiques et avantages

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable