L4762

Loperamide hydrochloride

98-102% (USP), powder, Ca2+ channel blocker

• Synonyme(s) : 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride
• Formule empirique (notation de Hill) : C₂₉H₃₃ClN₂O₂ · HCl
• CAS Number: 34552-83-5
• Poids moléculaire : 513.50
• Numéro CE : 252-082-4
• Numéro MDL: MFCD00058581
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278042
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Loperamide hydrochloride,
• Niveau de qualité: 200
• Auteur: Johnson & Johnson
• Chaîne SMILES: Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4
• InChI: 1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H
• Clé InChI: PGYPOBZJRVSMDS-UHFFFAOYSA-N
• Informations sur le gène: human ... OPRM1(4988)

Description

Application

Loperamide hydrochloride (HCl) has been used in inflammatory pain experiments and to assess the functionality of proteins. 54

Actions biochimiques/physiologiques

Loperamide hydrochloride (HCl) is a non-selective Ca²⁺ channel blocker. At nanomolar concentrations, it binds to μ-opioid receptors. Loperamide HCl does not cross the blood-brain barrier.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Notes préparatoires

Slightly soluble in water and dilute acids, freely soluble in methanol and in chloroform, soluble in ethanol (95%).

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 + P330 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges